219A
�シィ�ス��ス��ス抵ス費ス難ス��ス��ス�譬ェ蠑丈シ夂、セ
Heartseed株式会社
Pharmaceutical
Heartseed Inc. develops and commercializes iPS cell-derived cardiomyocyte replacement therapy for heart failure. The company's lead product is HS-001 for heart failure with reduced ejection fraction indications, including dilated cardiomyopathy, old myocardial infraction, and dilated phase of hypertrophic cardiomyopathy. It also develops products using autologous iPSC and HLA knock-out iPSC. In addition, the company offers differentiation induction, mass culture, purification, and myocardial globule production technology. The company was incorporated in 2015 and is headquartered in Tokyo, Japan.
Read more
← Companies
Overview
Filings & Signals
Ownership
Financials
▾ Collapse Charts
Income Statement
Balance Sheet
Cash Flow
Ratios & Per Share
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
Net Sales
¥3.0B
¥874M
Gross Profit
¥3.0B
¥874M
SG&A
¥2.8B
¥1.9B
Operating Income
¥272M
¥-1.0B
Non-Operating Income
¥59M
¥262M
Interest Income
¥6M
¥0M
Non-Operating Expenses
¥42M
¥42M
Interest Expense
¥0M
¥0M
Ordinary Income
¥289M
¥-819M
Pre-tax Income
¥289M
¥-819M
Income Taxes
¥98M
¥-6M
Current Tax
¥102M
¥5M
Deferred Tax
¥-3M
¥-11M
Net Income (owners)
¥191M
¥-813M
EBITDA
¥325M
¥-997M
EPS
¥8.44
¥-49.43
Shares Outstanding
22.9M
22.2M
Shares Issued (total)
22.9M
22.2M
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
Total Assets
¥7.7B
¥7.1B
Current Assets
¥7.1B
¥6.4B
Cash & Deposits
¥6.8B
¥5.3B
Trade Receivables
—
¥768M
Non-Current Assets
¥532M
¥664M
PP&E
¥431M
¥456M
Total Liabilities
¥481M
¥444M
Current Liabilities
¥320M
¥282M
Taxes Payable
¥9M
¥54M
Non-Current Liabilities
¥161M
¥162M
Deferred Tax Liab.
—
¥3M
Total Equity
¥7.2B
¥6.6B
Capital Stock
¥1.3B
¥1.1B
Capital Surplus
¥8.4B
¥8.2B
Retained Earnings
¥-2.6B
¥-2.8B
Equity (owners)
¥7.2B
¥6.6B
Net Cash ⓘ
¥6.8B
¥5.3B
NCAV ⓘ
¥6.7B
¥6.0B
NCAV/Share
¥291
¥268
BV/Share
¥315
¥297
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
Operating CF
¥1.1B
¥-1.3B
Taxes Paid
¥-107M
¥-3M
Interest Paid
¥-0M
¥-0M
D&A
¥53M
¥42M
Investing CF
¥73M
¥-67M
CapEx
¥29M
¥14M
Financing CF
¥376M
¥2.1B
Free Cash Flow
¥1.1B
¥-1.4B
Net Change in Cash
¥1.5B
¥709M
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
ROE
2.8%
-12.3%
ROA
2.6%
-11.5%
EPS
¥8.44
¥-49.43
BPS
¥314.56
¥297.44
FCF/Share
¥46
¥-61
NCAV/Share
¥291
¥268
Event Timeline
S Shareholder
A Capital Signal
▾ Hide Chart
Large Shareholder Reports 22
Date Activist Stake Event Flag Demands Source
2025-12-17
SBI Investment Co., Ltd.
17.56%
+3.75%
correction
Passive
—
2025-12-17
SBI Investment Co., Ltd.
16.16%
+2.35%
correction
Passive
—
2025-12-17
SBI Investment Co., Ltd.
14.96%
+1.15%
correction
Passive
—
2025-12-17
SBI Investment Co., Ltd.
13.81%
correction
Passive
—
2025-12-17
SBI Investment Co., Ltd.
12.79%
-1.02%
correction
Passive
—
2025-12-15
SBI Investment Co., Ltd.
12.05%
-0.74%
change
Passive
—
2025-09-26
SBI Investment Co., Ltd.
12.79%
-1.02%
change
Passive
—
2025-09-17
SBI Investment Co., Ltd.
13.81%
-1.15%
change
Passive
—
2025-08-29
SBI Investment Co., Ltd.
14.96%
-1.2%
change
Passive
—
2025-08-22
SBI Investment Co., Ltd.
16.16%
-1.4%
change
Passive
—
2025-08-21
AKIYAMA TAKUMI
4.87%
-0.22%
change
Passive
—
2025-07-23
SBI Investment Co., Ltd.
17.56%
-0.22%
change
Passive
—
2025-05-20
FURUKAWA TOSHIHARU
4.08%
correction
Passive
—
2025-05-13
FURUKAWA TOSHIHARU
4.08%
-1.01%
change
Passive
—
2024-10-11
Angel Bridge Deal-by-Deal Fund 5 Inc.
0.79%
-4.47%
change
Passive
—
2024-10-10
Angel Bridge Deal-by-Deal Fund 5 Inc.
5.26%
-1.85%
change
Passive
—
2024-10-04
Angel Bridge Deal-by-Deal Fund 5 Inc.
7.11%
-1.48%
change
Passive
—
2024-08-06
SBI Investment Co., Ltd.
17.78%
initial_5pct
Passive
—
2024-08-01
FUKUDA KEIICHI
14.55%
initial_5pct
Passive
—
2024-08-01
Angel Bridge Deal-by-Deal Fund 5 Inc.
8.59%
initial_5pct
Passive
—
2024-08-01
FURUKAWA TOSHIHARU
5.09%
initial_5pct
Passive
—
2024-08-01
AKIYAMA TAKUMI
5.09%
initial_5pct
Passive
—
Top 10 Shareholders
Ownership DNA
#
Shareholder
Shares (thou.)
% of Total
1
福田 惠一
3,146,000
13.76%
2
SBI Ventures Two㈱
2,236,800
9.79%
3
古川 俊治
920,000
4.02%
4
新村 健造
842,400
3.69%
5
㈱イノベーション企画21
650,000
2.84%
6
㈱JMDC
461,600
2.02%
7
秋山 琢己
441,000
1.93%
8
五味 大輔
350,000
1.53%
9
SBI AI&Blockchain投資事業有限責任組合
264,700
1.16%
10
㈱メディパルホールディングス
250,000
1.09%
Domestic Nominees
0.0%
-2.8% vs 2024
Trust bank custodians — GPIF, pensions, investment trusts
Foreign Custodians
0.0%
+0.0% vs 2024
Sub-custodians for foreign asset managers
Direct / Strategic
41.8%
-11.2% vs 2024
Named entities with disclosed investment intent
Shareholder
Trend
2024
2025
福田 惠一
14.40%
13.76%
-0.64%
SBI Ventures Two
10.06%
9.79%
-0.27%
古川 俊治
5.04%
4.02%
-1.02%
新村 健造
↑
2.67%
3.69%
+1.02%
㈱イノベーション企画21
NEW ENTRY
—
—
2.84%
NEW
㈱JMDC
↑
2.08%
2.02%
-0.06%
秋山 琢己
5.04%
1.93%
-3.11%
五味 大輔
NEW ENTRY
—
—
1.53%
NEW
SBI AI&Blockchain投資事業有限責任組合
6.93%
1.16%
-5.77%
㈱メディパルホールディングス
NEW ENTRY
—
—
1.09%
NEW
河西 佑太郎
last seen 2024
Exited Top 10
3.60%
—
Astellas Venture Management LLC.
last seen 2024
Exited Top 10
3.19%
—
日本カストディ銀行
last seen 2024
Exited Top 10
2.77%
—
Concentration (HHI)
ⓘ
450
336
2 fiscal years · top-10 holders per year · >2,500 HHI = high concentration · entity-resolved