4572
Carna Biosciences, Inc.
カルナバイオサイエンス株式会社
Healthcare · Biotechnology
Carna Biosciences, Inc., a clinical-stage biopharmaceutical company, researches and develops drug therapies to treat unmet medical needs in Japan. It offers kinase proteins and other protein products, including tyrosine, serine/threonine, lipid, inactive kinase, and pseudokinase; GST-tagged and Biotinylated; Protein Substrate; and Luciferase PPI Stable Cell Lines, such as GPCR and protein-protein interactions. The company also provides activity-based biochemical screening/profiling assay services comprising mobility shift assay/IMAP and AFP-Glo assay; and cell-based assay services which include NanoBRET TE intracellular kinase assay and split luciferase protein-protein interaction detection assay. In addition, it engages in developing monzosertib, an orally bioavailable small molecule inhibitor of cell division cycle 7 (CDC7) kinase that is in Phase 1 to treat various cancer cell lines, including solid and blood cancers; docirbrutinib, an orally bioavailable, non-covalent pan-inhibitor of wild type and mutant Bruton's tyrosine kinases for the treatment of chronic lymphocytic leukemia and other B-cell malignancies; and sofnobrutinib, a non-covalent Bruton's tyrosine kinases which is in clinical development to treat inflammatory and immune disorders. Carna Biosciences, Inc. was incorporated in 2003 and is headquartered in Kobe, Japan.
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Overview
Filings & Signals
Ownership
Financials
▾ Collapse Charts
Income Statement
Balance Sheet
Cash Flow
Ratios & Per Share
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
FY 2023
EDINET ↗
FY 2022
EDINET ↗
FY 2021
EDINET ↗
Net Sales
¥579M
¥636M
¥1.6B
¥1.4B
¥2.0B
Cost of Sales
¥191M
¥171M
¥175M
¥172M
¥135M
Gross Profit
¥388M
¥466M
¥1.5B
¥1.2B
¥1.9B
SG&A
¥2.5B
¥2.5B
¥2.6B
¥2.5B
¥2.4B
Operating Income
¥-2.1B
¥-2.1B
¥-1.1B
¥-1.3B
¥-531M
Non-Operating Income
¥6M
¥44M
¥1M
¥6M
¥24M
Dividend Income
¥2M
¥0M
¥0M
¥0M
¥0M
Interest Income
¥4M
¥15M
¥0M
¥0M
¥0M
Non-Operating Expenses
¥76M
¥49M
¥10M
¥15M
¥16M
Interest Expense
¥10M
¥3M
¥3M
¥5M
¥4M
Ordinary Income
¥-2.1B
¥-2.1B
¥-1.1B
¥-1.3B
¥-523M
Pre-tax Income
¥-2.2B
¥-2.2B
¥-1.1B
¥-1.3B
¥-532M
Income Taxes
¥2M
¥5M
¥22M
¥26M
¥2M
Current Tax
¥3M
¥5M
¥22M
¥26M
¥8M
Deferred Tax
¥-1M
¥-0M
¥-0M
¥-0M
¥-6M
Net Income (owners)
¥-2.2B
¥-2.2B
¥-1.2B
¥-1.3B
¥-534M
Comprehensive Income
¥-2.2B
¥-2.1B
¥-1.1B
¥-1.3B
¥-511M
EBITDA
—
¥-2.0B
¥-1.1B
¥-1.2B
¥-512M
EPS
¥-113.62
¥-121.64
¥-68.62
¥-99.10
¥-42.10
Shares Outstanding
19.1M
19.1M
17.1M
14.2M
13.3M
Shares Issued (total)
19.2M
19.1M
17.2M
14.2M
13.3M
Treasury Shares
0.0M
0.0M
0.0M
0.0M
0.0M
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
FY 2023
EDINET ↗
FY 2022
EDINET ↗
FY 2021
EDINET ↗
Total Assets
¥1.2B
¥2.8B
¥4.3B
¥4.3B
¥5.4B
Current Assets
¥1.2B
¥2.7B
¥4.2B
¥4.1B
¥5.3B
Cash & Deposits
¥517M
¥2.1B
¥2.9B
¥3.4B
¥3.8B
Trade Receivables
¥101M
¥87M
¥788M
¥182M
¥1.2B
Non-Current Assets
¥54M
¥34M
¥158M
¥162M
¥114M
PP&E
—
—
¥105M
¥100M
¥52M
Intangible Assets
—
—
¥1M
¥2M
¥3M
Investment Securities
¥29M
—
—
—
—
Total Liabilities
¥920M
¥297M
¥472M
¥625M
¥1.1B
Current Liabilities
¥168M
¥223M
¥376M
¥436M
¥775M
ST Debt
¥8M
¥20M
¥120M
¥120M
¥212M
Taxes Payable
¥2M
¥29M
¥28M
¥31M
¥24M
Non-Current Liabilities
¥752M
¥74M
¥96M
¥188M
¥342M
Total LT Borrowings
—
¥8M
¥28M
¥148M
¥300M
Total Equity
¥309M
¥2.5B
¥3.9B
¥3.6B
¥4.3B
Capital Stock
¥15M
¥2.4B
¥2.1B
¥1.4B
¥1.1B
Capital Surplus
¥2.2B
¥6.2B
¥5.8B
¥5.1B
¥4.8B
Retained Earnings
¥-2.0B
¥-6.3B
¥-4.1B
¥-2.9B
¥-1.6B
Treasury Stock
¥-0M
¥-0M
¥-0M
¥-0M
¥-0M
AOCI
¥79M
¥83M
¥49M
¥31M
¥14M
Equity (owners)
¥231M
¥2.4B
¥3.8B
¥3.6B
¥4.3B
Total Interest-Bearing Debt ⓘ
¥8M
¥28M
¥148M
¥268M
¥512M
Net Cash ⓘ
¥508M
¥2.1B
¥2.7B
¥3.1B
¥3.3B
NCAV ⓘ
¥255M
¥2.4B
¥3.7B
¥3.5B
¥4.2B
NCAV/Share
¥13
¥128
¥217
¥245
¥316
BV/Share
¥12
¥125
¥223
¥253
¥323
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
FY 2023
EDINET ↗
FY 2022
EDINET ↗
FY 2021
EDINET ↗
Operating CF
¥-2.2B
¥-1.4B
¥-1.7B
¥-708M
¥-1.5B
Taxes Paid
¥14M
¥-19M
¥-33M
¥-19M
¥41M
Interest Paid
¥-4M
¥-3M
¥-3M
¥-5M
¥-4M
D&A
—
¥31M
¥36M
¥34M
¥19M
Investing CF
¥-25M
¥-13M
¥-11M
¥-126M
¥-42M
CapEx
¥9M
¥13M
¥12M
¥126M
¥42M
Purchase Investments
¥-16M
—
—
—
—
Financing CF
¥605M
¥567M
¥1.2B
¥367M
¥1.1B
LT Debt Repaid
¥-20M
¥-120M
¥-120M
¥-211M
¥-162M
Free Cash Flow
¥-2.2B
¥-1.4B
¥-1.7B
¥-834M
¥-1.6B
Net Change in Cash
¥-1.6B
¥-781M
¥-490M
¥-439M
¥-481M
Metric
FY 2025
EDINET ↗
FY 2024
EDINET ↗
FY 2023
EDINET ↗
FY 2022
EDINET ↗
FY 2021
EDINET ↗
ROE
-156.0%
-68.6%
-30.7%
-33.9%
-12.4%
ROA
-108.5%
-61.2%
-26.8%
-27.8%
-9.8%
EPS
¥-113.62
¥-121.64
¥-68.62
¥-99.10
¥-42.10
BPS
¥16.16
¥129.62
¥226.16
¥255.04
¥323.54
FCF/Share
¥-113
¥-73
¥-99
¥-59
¥-119
NCAV/Share
¥13
¥128
¥217
¥245
¥316
Event Timeline
S Shareholder
A Capital Signal
▾ Hide Chart
Large Shareholder Reports 17
Date Activist Stake Event Flag Demands Source
2026-05-20
Cantor Fitzgerald Europe
31.5%
-3.4%
change
Passive
—
2026-05-20
Cantor Fitzgerald Europe
34.9%
correction
Passive
—
2026-05-20
Cantor Fitzgerald Europe
33.2%
-1.7%
correction
Passive
—
2026-05-11
Cantor Fitzgerald Europe
33.2%
-1.7%
change
Passive
—
2026-04-28
Athos Capital Limited
4.87%
correction
Passive
—
2026-04-16
Athos Capital Limited
4.87%
-2.46%
change
Passive
—
2026-02-20
Cantor Fitzgerald Europe
34.9%
+19.88%
change
Passive
—
2026-01-13
Gomi Daisuke
5.14%
initial_5pct
Passive
—
2025-11-28
Cantor Fitzgerald Europe
15.02%
+5.34%
change
Passive
—
2025-10-06
Cantor Fitzgerald Europe
9.68%
correction
Passive
—
2025-10-03
Cantor Fitzgerald Europe
9.68%
initial_5pct
Passive
—
2024-10-21
Athos Capital Limited
7.33%
initial_5pct
Passive
—
2024-10-21
Morgan Stanley & Co. International plc
3.33%
-2.2%
change
Passive
—
2024-10-04
Morgan Stanley & Co. International plc
5.53%
initial_5pct
Passive
—
2024-01-09
Nomura Securities Co.,Ltd.
3.05%
-2.98%
change
Passive
—
2023-11-20
Nomura Securities Co.,Ltd.
6.03%
initial_5pct
Passive
—
2023-08-07
Cantor Fitzgerald & Co.
—
exit
Passive
—
Top 10 Shareholders
Ownership DNA
Cross-Holdings Tracker 1
#
Shareholder
Shares (thou.)
% of Total
1
MSIP CLIENT SECURITIES
MSIP CLIENT SECURITIES(常任代理人 モルガン・スタンレーMUFG証券株式会社)
955,612
4.99%
2
川村 剛
555,500
2.90%
3
ONO PHARMACEUTICAL CO., LTD.
小野薬品工業株式会社
504,500
2.63%
4
上原 俊彦
500,000
2.61%
5
堀田 和男
468,800
2.44%
6
吉野 公一郎
333,900
1.74%
7
小川 義水
255,000
1.33%
8
BNY GCM CLIENT ACCOUNT JPRD AC ISG (FE-AC)
BNY GCM CLIENT ACCOUNT JPRD AC ISG (FE-AC)(常任代理人 株式会社三菱UFJ銀行)
195,241
1.02%
9
BNYM SA/NV FOR BNYM FOR BNYM GCM CLIENT ACCTS M ILM FE
BNYM SA/NV FOR BNYM FOR BNYM GCM CLIENT ACCTS M ILM FE(常任代理人 株式会社三菱UFJ銀行)
180,304
0.94%
10
鈴木 隆啓
149,000
0.77%
Domestic Nominees
0.0%
+0.0% vs 2024
Trust bank custodians — GPIF, pensions, investment trusts
Foreign Custodians
0.9%
-2.6% vs 2024
Sub-custodians for foreign asset managers
Direct / Strategic
20.4%
+1.7% vs 2024
Named entities with disclosed investment intent
Shareholder
Trend
2023
2024
2025
MSIP CLIENT SECURITIES
—
6.70%
4.99%
-1.71%
川村 剛
NEW ENTRY
—
—
—
2.90%
NEW
ONO PHARMACEUTICAL CO., LTD.
小野薬品工業
2.94%
2.64%
2.63%
-0.01%
上原 俊彦
2.14%
2.12%
2.61%
+0.49%
堀田 和男
1.76%
1.83%
2.44%
+0.61%
吉野 公一郎
1.94%
1.74%
1.74%
小川 義水
↑
—
1.04%
1.33%
+0.29%
BNY GCM CLIENT ACCOUNT JPRD AC ISG (FE-AC)
BNY GCM CLIENT ACCOUNT JPRD AC ISG (FE-AC)
—
1.05%
1.02%
-0.03%
BNY Mellon
—
2.45%
0.94%
-1.51%
鈴木 隆啓
1.39%
1.57%
0.77%
-0.80%
State Street
last seen 2024
Exited Top 10
1.64%
1.12%
—
JP Morgan
last seen 2023
Exited Top 10
1.67%
—
—
野村證券
last seen 2023
Exited Top 10
3.29%
—
—
楽天証券
last seen 2023
Exited Top 10
2.99%
—
—
Concentration (HHI)
ⓘ
47
75
60
3 fiscal years · top-10 holders per year · >2,500 HHI = high concentration · entity-resolved
Portfolio Book Value
¥17M
Holdings
1
Book value in ¥M · ↓ reduced · ↑ increased vs prior year · M = mutual holding
· Only one fiscal year available